Angiogenin complexes (ANGex) and uses thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S006900, C514S021800, C530S350000

Reexamination Certificate

active

07601689

ABSTRACT:
Stabilized angiogenin compositions and methods of preparing a stabilized angiogenin compositions by non-covalent immobilization on a naturally occurring substrate, such as a protein, lipid, nucleic acid or nucleotide substrate, are disclosed.

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Acharya, et al. “Crystal Structure of Human Angiogenin Reveals the Structural Basis for its Functional Divergence from Ribonuclease,”Proc. Natl. Acad. Sci. USA, vol. 91, pp. 2915-2919, Apr. 1994.
Hu, et al. A Putative Angiogenin Receptor in Angiogenin-Responsive Human Endothelial Cells,Proc. Natl. Acad. Sci. USA, vol. 94, pp. 2204-2209, Mar. 1997.
King, et al. Neovascularisation of the Meniscus with Angiogenin, An Experimental Study in Rabbits,The Journal of Bone and Joint Surgery, vol. 73-B, No. 4, pp. 587-590, Jul. 1991.
Maiti, et al. “Isolation and Characterization of an Angiogenin-Like Protein from Goat Plasma,”Protein and Peptide Letters, vol. 9, No. 4, pp. 283-288, 2002.
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