Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-06-26
2007-06-26
Russel, Jeffrey Edwin (Department: 1654)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S330000, C530S331000
Reexamination Certificate
active
10380983
ABSTRACT:
The present invention relates to the use of a compound of formula I:in which, A1is the radical corresponding to D- or L-Ser,A2is the radical corresponding to D- or L-Asp or Glu,A3is the radical corresponding to D- or L-Lys, Arg or Gm,A4is the radical corresponding to D- or L-Pro,R1and R2are chosen, independently, from H, C1–C12-alkyl which may or may not be substituted, C7–C20-arylalkyl which may or may not be substituted, R4CO or R4COO, R4being C1–C12-alkyl which may or may not be substituted, or C7–C20-arylalkyl which may or may not be substituted;among the substitutions, mention should be made of OH, NH2or COOH,X1and X2are peptide or pseudopeptide bonds,X3is CO or CH2andR3is OH, NH2, C1–C1-alkoxy or NH-X4-CH2-Z, X4is a normal or branched C1–C12hydrocarbon, and Z is H, OH, CO2H or CONH2,or the corresponding tripeptides comprising the radicals A1, A2, A3,and also the pharmacautically acceptable salts, for the preparation of a medicament for treating pathologies which may benefit from stimulation of angiogenesis.
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patent: 6815426 (2004-11-01), Scialdone et al.
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patent: WO00/06190 (2000-02-01), None
Huff, T. et al, “.beta.-Thymosins, small acidic peptides with multiple functions,” The International Journal of Biochemistry & Cell Biology, vol. 33, No. 3, 2001, pp. 205-220.
Bakala Joanna
Bignon Jérôme
Cheviron Nathalie
Fromes Yves
Lawrence Françoise
Centre National de la Recherche Scientfique
Russel Jeffrey Edwin
Steptoe & Johnson LLP
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