Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1998-06-18
2000-02-22
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 53, 514 62, 5361231, 536118, A61K 31715, C07H 1312
Patent
active
060280611
ABSTRACT:
The present invention is based on the unexpected discovery that a molecule having as its major repeating units N-acetylglucosamine alternating in sequence with 2-O-sulfated uronic acid, inhibits FGF mitogenicity, and thus is useful in inhibiting angiogenesis. Additionally, the molecule has low toxicity and inhibits FGF mitogenicity without affecting anticoagulant activity. One preferred molecule is a glycosaminoglycan such as archaran sulfate. The molecules are in pharmaceutical compositions that can be used in the treatment of diseases which are angiogenesis-dependent.
REFERENCES:
patent: 4990502 (1991-02-01), Lormeau et al.
patent: 5646136 (1997-07-01), Petrow et al.
Guimond, et al., Biol. Chem. 268, 23906-23914.
Wang et al., Biochemical and Biophysical Research Communications, 235, 396-373, Jun. 18, 1997.
Bernfield Merton
Kim Yeong Shik
Linhardt Robert J.
Children's Medical Center Corp
Conlin David G.
Knode Marian C.
Resnick David S.
The University of Iowa Research Foundation
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