Angiogenesis inhibitors and pharmaceutical/cosmetic...

Details Angiogenesis inhibitors and pharmaceutical/cosmetic... Angiogenesis inhibitors and pharmaceutical/cosmetic...

2008-07-08

2008-07-08

Puttlitz, Karl (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S055000, C560S064000, C568S376000, C514S532000

Reexamination Certificate

active

11642846

ABSTRACT:
Novel derivatives of fumagalone have the general formula (I):and are useful angiogenes is inhibitors; these can be formulated into pharmaceutical compositions suited for human or veterinary medicine, or can be formulated into cosmetic compositions.

REFERENCES:
patent: 6803382 (2004-10-01), Eustache et al.
patent: WO 03/040119 (2003-05-01), None
http://www.medicinenet.com/rosacea/article.htm last visited on May 10, 2007.
Rodeschini et al., Journal of Organic Chemistry (2005), 70(6), 2409-2412.
Rodeschini et al., “Enantioselective Approaches to Potential MetAP-2 Reversible Inhibitors”, XP-002352284, J. Org. Chem., 2005, pp. 2409-2412, vol. 70, American Cancer Society, published on Web Feb. 18, 2005.
Rodeschini et al., “MetAP-2 Inhibitors Based on the Fumagillin Structure, Side-Chain Modification and Ring-Substituted Analogues”, XP-002329329, J. Org. Chem., 2004, pp. 357-373, vol. 67, American Cancer Society, published on Web Dec. 23, 2003.
Zhou et al., “Fumagalone, a Reversible Inhibitor of Type 2 Methionine Aminopeptidase and Angiogenesis”, XP-002329330, J. Med. Chem., 2003, pp. 3452-3454, vol. 46, American Cancer Society, published on Web Jul. 9, 2003.

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