Angiogenesis inhibitor comprising meteorin as an active...

Details Angiogenesis inhibitor comprising meteorin as an active... Angiogenesis inhibitor comprising meteorin as an active...

2011-06-14

2011-06-14

Ulm, John D (Department: 1649)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C514S001100, C514S007600

Reexamination Certificate

active

07960345

ABSTRACT:
The present invention relates to an angiogenesis inhibitor comprising meteorin as an active ingredient that is highly expressed in astrocytes of the brain and retina in the late embryonic stage and after the birth of a mouse. It is in particular highly detected in astrocyte endfeet surrounding blood vessels and promotes the expression of thrombospondin-1/-2 (TSP-1/-2) via autocrine pathway and thus inhibits angiogenesis. The meteorin of the present invention can be effectively used for pharmaceutical compositions and health foods that prevent vascular diseases by inhibiting angiogenesis.

REFERENCES:
patent: 5192744 (1993-03-01), Bouck et al.
patent: 5200397 (1993-04-01), Deutch et al.
Nishino, J et al. “Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension”;The EMBO J. 23(9)1998-2008 (2004).
Park, Ja et al.l “Isolation of a Hypoxia/Reoxygenation Regulatory Factor in Rat Astrocytes”;Yakhak Hoeji50(2)124-128 (2006) (abstract).

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