Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-10-24
2000-05-02
Davenport, Avis M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 514 14, 530300, 530307, 530324, 530325, 530326, 530327, 530350, A61K 3800, C07K 500, C07K 700
Patent
active
060572906
ABSTRACT:
An angiogenesis inhibitor comprising a cysteine protease inhibitory compound. As the preferable cysteine protease inhibitory compound, epoxysuccinic acid compounds, peptide halohydrazide compounds, calpain inhibitory compounds, compounds of the formula (I) ##STR1## and compounds of the formula (VI) ##STR2## can be used. The angiogenesis inhibitor of the present invention suppresses new formation of blood vessels in the living tissues, so that it can be used as a superior therapeutic or prophylactic agent of angiogenesis associated with wound healing, inflammation, growth of tumor and the like; and angiogenesis as seen in diabetic retinopathy, prematurity retinopathy, retinal venous occlusion, senile discoid macular degeneration and the like, as well as for prevention of metastasis of tumors.
REFERENCES:
P. Bagavandoss et al., "Recombinant Truncated Thrombospondin-1 Monomer Modulates Endothelial Cell Plasminogen Activator Inhibitor 1 Accumulation and Proliferation In vitro", Biochemical and Biophysical Research Communications, vol. 92, No. 2, pp. 325-332, 1993.
Patent Abstracts of Japan, vol. 013, No. 101, Mar. 9, 1989 & JP 63 275576 A, Nov. 14, 1988 * abstract *.
Patent Abstracts of Japan, vol. 013, No. 101, Mar. 9, 1989 & JP 63 275575, Nov. 14, 1988, * abstract *.
Azuma Mitsuyoshi
Fukiage Chiho
Inoue Jun
Nakamura Masayuki
Yoshida Yuka
Davenport Avis M.
Senju Pharmaceutical Co. Ltd.
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