Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1989-06-19
1990-12-04
Griffin, Ronald W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
536 11, 536 551, 536123, A61K 31715, C02H 100
Patent
active
049754220
ABSTRACT:
The present invention discloses an angiogenesis inhibitor containing as an active ingredient protein-polysaccharides produced by extraction of mycelia or fruit bodies obtained from culture of a Basidiomycete belonging to a genus Coriolus.
The protein-polysaccharide contains about 18 to about 38% by weight of protein, being free from protein-polysaccharides having molecular weight of less than 5,000.
More in detail, said protein-polysaccharides of the present invention contain 3 to 6% of nitrogen, a polysaccharide portion thereof, as the main fraction, is composed of .beta.-D-glucan and this glucan portion has branched structures containing 1.fwdarw.3, 1.fwdarw.4 and 1.fwdarw.6 bonds, wherein the protein-component amino acids are mostly acidic amino acids of aspartic acid and glutamic acid, and neutral amino acids of valine and leucine, while the basic amino acids of lysine and alginine are small in content, and the protein-polysaccharide is soluble in water but hardly soluble in methanol, pyridine, chloroform, benzene and hexane and starts to be gradually decomposed at about 120.degree. C.
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Fujii Takayoshi
Kanoh Tamotsu
Matsunaga Ken-ichi
Saito Ken-ichi
Griffin Ronald W.
Kureha Kagaku Kogyo Kabushiki Kaisha
Webber Pamela S.
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