Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-08-30
2011-08-30
Stoica, Elly-Gerald (Department: 1647)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C424S192100, C424S185100, C435S069700, C435S328000, C536S023400, C530S350000
Reexamination Certificate
active
08008257
ABSTRACT:
A fusion protein comprising an arterial natriuretic factor (ANF) amino acid sequence linked to an albumin amino acid sequence by one or more peptide bonds is provided. The ANF amino acid sequence may be linked to the N-terminal, the C-terminal, or both the N-terminal and the C-terminal of the albumin amino acid sequence. Also provided is a nucleic acid molecule encoding the fusion protein and a vector comprising the nucleic acid molecule. Methods for treating or preventing cardiovascular or renal disease comprising administration of an effective amount of the fusion protein, or nucleic acid encoding the fusion protein, are also disclosed.
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de Bold Adolfo J.
Kuroski De Bold Mercedes L.
Sheffield William
Hovey & Williams, LLP
McMaster University
Stoica Elly-Gerald
University of Ottawa Heart Institute
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