Anergy genes

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing compound containing saccharide radical

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435 6, 435 71, 436 94, 536 231, 536 253, C12P 1934, C12Q 168, G01N 3300, C07H 2102

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057472998

ABSTRACT:
Methods and compositions are provided for identifying genes associated with induction of anergy in T-cells and the use of the nucleic acids or proteins as diagnostics for monitoring induction of tolerance for the presence of tolerized T-cells in a physiological sample, or elucidating the pathway to anergy or activation in T-cells. A cysteine string protein is found to indicate quiescent T-cells and is lost with anergic T-cells.

REFERENCES:
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Kuhrober et al., "Vaccination with T Cell Receptor Peptides Primes Anti-Receptor Cytotoxic T Lymphocytes (CTL) and Anergizes T Cells Specifically Recognized by These CTL," Eur. J. Immunol. (1994), 24:1172-1180.
Gregorian et al., "Induction of Peripheral Tolerance with Peptide Specific Anergy in Experimental Autoimmune Neuritis," Cell Immunol. (1993), 150:298-310.
Martin and Davies, "T Cells and Human Autoimmune Thyroid Disease," Thyroid (1992), 2:247-261.
Kang et al., "Transactivation by AP-1 is a Molecular Target of T Cell Clonal Anergy," Science (1992), 257:1134-1138.
LaSalle et al., Early signalling defects in human T-cells anergized by T-cell presentation of autoantigen, J. Exp. Med. v. 176, pp. 177-186, Jul. 1992.
Mastrogiacomo et al., Cysteine string proteins: a potential link between synaptic vesicles and presynaptic Ca2+ channels, Science v. 263, pp. 981-982, Feb. 1994.
Liang et al., Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction, Science v. 257, pp. 967-971, Aug. 1992.
Ronchese et al., Functionally distinct subsites on a class II major histocompatability complex molecule, Nature v. 329, pp. 254-256, Sep. 1987.
Sloan-Lancaster et al., Induction of T-cell anergy by altered T-cell receptor ligand on live antigen presenting cells, Nature v. 363, pp. 156-159, May 1993.
Kennedy et al., Specific immune regulation of chronic relapsing experimental allergic encephalomyelitis in mice, Journal of Immunology, v. 141, pp. 2986-2993, Nov. 1988.

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