Androstane derivatives substituted by a quaternary ammonium grou

Details Androstane derivatives substituted by a quaternary ammonium grou Androstane derivatives substituted by a quaternary ammonium grou

1993-10-27

1997-01-07

Shah, Mukund J

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 96, 540 97, C07J 4300, A61K 3158

Patent

active

055917356

ABSTRACT:
There is disclosed novel, therapeutically active androstane derivatives having neuromuscular blocking effect, which are substituted by a quaternary ammonium group in 16-position; pharmaceutically composition containing them; process for producing them; and novel intermediates for the production.

REFERENCES:
patent: 4177190 (1979-12-01), Tuba et al.
Buckett et al, Jour. of Med. Chemistry vol. 16 pp. 1116-1124 (1973).
Zoltan Tuba et al., "Structure-Activity Relationships of Steroidal Neuromuscular Blocking Agents", Molecular Structure and Bioilogical Activity of Steroids, Chapter 11, pp. 359-397 (Aug. 1992).

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