Androgen synthesis inhibitors

Details Androgen synthesis inhibitors Androgen synthesis inhibitors

1997-02-05

1999-11-30

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Cyclopentanohydrophenanthrene ring system doai

540 96, A61K 3158, C07J 4300

Patent

active

059943343

ABSTRACT:
This invention relates to novel inhibitors of androgen synthesis that are useful in the treatment of prostate cancer and benign prostatic hypertrophy. Novel compounds according to the present invention are steroid derivatives. These compounds are preferably substituted at the 17 position, with a heterocyclic or nonheterocyclic radical, for example, a 5-membered heterocyclic ring. The present invention also provides methods of synthesizing these novel compounds, pharmaceutical compositions containing these novel compounds, and methods of treating prostate cancer and benign prostatic hypertrophy using the androgen synthesis inhibitors of the present invention.

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