Androgen receptor coactivators

Details Androgen receptor coactivators Androgen receptor coactivators

2006-05-30

2006-05-30

Chernyshev, Olga N. (Department: 1649)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S069100, C435S320100, C536S023500, C530S350000

Reexamination Certificate

active

07052908

ABSTRACT:
Disclosed are androgen receptor-associated proteins, designated ARA24, ARA54, ARA55, and Rb, that have been demonstrated to interact with the androgen receptor to alter levels of androgen receptor-mediated transcriptional activation. Certain of these proteins interact with the androgen receptor in an androgen-dependent manner, whereas certain proteins may induce transcriptional activation in the presence of other ligands, such as E2 or HF. Also disclosed is a method of detecting androgenic or antiandrogenic activity using these proteins in a mammalian two-hybrid transient transfection assay.

REFERENCES:
patent: 5208263 (1993-05-01), Liao et al.
patent: 5674703 (1997-10-01), Woo et al.
patent: 5677336 (1997-10-01), Jones et al.
patent: 5789170 (1998-08-01), Chang et al.
patent: WO 97/44490 (1997-11-01), None
Anderson et al. Retinoblastoma protein in human breast carcinoma: immunohistochemical study using a new monoclonal antibody effective on routinely processed tissues. J Pathol. Sep. 1996;180(1):65-70.
Anzick et al. AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer. Science. Aug. 15, 1997;277(5328):965-8.
Beddow et al. The Ran/TC4 GTPase-binding domain: identification by expression cloning and characterization of a conserved sequence motif. Proc Natl Acad Sci U S A. Apr. 11, 1995;92(8):3328-32.
Blake et al. The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif. Oncogene. Apr. 1991;6(4):653-7.
Bookstein et al. Promoter deletion and loss of retinoblastoma gene expression in human prostate carcinoma. Proc Natl Acad Sci U S A. Oct. 1990;87(19):7762-6.
Bookstein et al. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science. Feb. 9, 1990;247(4943):712-5.
Borden et al. The solution structure of the RING finger domain form the acute promyelocytic leukaemia proto-oncoprotein PML. EMBO J. Apr. 3, 1995;14(7):1532-41.
Brooks et al. Allelic loss of the retinoblastoma gene in primary human prostatic adenocarcinomas. Prostate. Jan. 1995;26(1):35-9.
Cardoso et al. Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein. Hum Mol Genet. Apr. 1998;7(4):679-84.
Chamberlain et al. The length and location of CAG trinucleotide repeats in the androgen receptor N-terminal domain affect transactivation function. Nucleic Acids Res. Aug. 11, 1994;22(15):3181-6.
Chang et al. Suppression of Delta(5)-androstenediol-induced androgen receptor transactivation by selective steroids in human prostate cancer cells. Proc Natl Acad Sci U S A. Sep. 28, 1999;(20):11173-7.
Chen et al. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell. Sep. 22, 1989;58(6):1193-8.
Chen et al. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc Natl Acad Sci U S A. Jan. 9, 1996;93(1):465-9.
Crawford, Challenges in the management of prostate cancer. Br J Urol. Nov. 1992;70 Suppl 1:33-8.
Dowdy et al. Physical interaction of the retinoblastoma protein with human D cyclins. Cell. May 7, 1993;73(3):499-511.
Dynlacht et al. Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation. Cell. Aug. 9, 1991;66(3):563-76.
Fujimoto et al. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. J Biol Chem. Mar. 19, 1999;274(12):8316-21.
Gaddipati et al. Frequent detection of codon 877 mutation in the androgen receptor gene in advanced prostate cancers. Cancer Res. Jun. 1, 1994;54(11):2861-4.
Gregory et al. Androgen receptor expression in androgen-independent prostate cancer is associated with increased expression of androgen-regulated genes. Cancer Res. Dec. 15, 1998;58(24):5718-24.
Gregory, C.W. et al. A mechanism for androgen receptor-mediated prostate cancer recurrence after androgen deprivation therapy.Cancer Res61, 4315-4319. (2001).
Gu et al. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell. Nov. 13, 1992;71(4):701-8.
Han et al., Hormone status selects for spontaneous somatic androgen receptor variants that demonstrate specific ligand and cofactor dependent activities in autochthonous prostate cancer. J Biol Chem. Apr. 6, 2001;276(14):11204-13.
Heery et al. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. Jun. 12, 1997;387(6634):733-6.
Hillier et al. Wash U-Merck EST Project 1997. EMBL ACC No.: AA448471 (Jun. 10, 1997).
Hsiao et al. The linkage of Kennedy's neuron disease to ARA24, the first identified androgen receptor polyglutamine region-associated coactivator. J Biol Chem. Jul. 16, 1999;274(29):20229-34.
Hsiao, P., and Chang, C. Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells. J Biol Chem. Aug. 6, 1999;274(32):22373-9.
Ishida et al. Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new ‘RING-finger’ motif. Gene. Jul. 30, 1993;129(2):249-55.
Kaelin et al. Identification of cellular proteins that can interact specifically with the T/E1A-binding region of the retinoblastoma gene product. Cell. Feb. 8, 1991;64(3):521-32.
Kang et al. Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. J Biol Chem. Mar. 26, 1999;274(13):8570-6.
Kang et al. From transforming growth factor-beta signaling to androgen action: identification of Smad3 as an androgen receptor coregulator in prostate cancer cells. Proc Natl Acad Sci U S A. Mar. 13, 2001;98(6):3018-23.
Kemppainen et al. Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. J Biol Chem. Jan. 15, 1992;267(2):968-74.
Kokontis et al. Expression and function of normal and LNCaP androgen receptors in androgen-insensitive human prostatic cancer cells. Altered hormone and antihormone specificity in gene transactivation. Receptor. 1991;1(4):271-9.
Kranenburg et al. Cyclin-dependent kinases and pRb: regulators of the proliferation-differentiation switch. FEBS Lett. Jun. 26, 1995;367(2):103-6.
La Spada et al. Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy. Nature. Jul. 4, 1991;352(6330):77-9.
Laemmli, Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. Aug. 15, 1970;227(259):680-5.
Lee et al. Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily. Proc Natl Acad Sci U S A. Dec. 21, 1999;96(26):14724-9.
Lee et al. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. Mol Endocrinol. Feb. 1995;9(2):243-54.
Lovering et al. Identification and preliminary characterization of a protein motif related to the zinc finger. Proc Natl Acad Sci U S A. Mar. 15, 1993;90(6):2112-6.
Ludlow et al. Specific enzymatic dephosphorylation of the retinoblastoma protein. Mol Cell Biol. Jan. 1993;13(1):367-72.
McPhaul et al. Genetic basis of endocrine disease. 4. The spectrum of mutations in the androgen receptor gene that causes androgen resistance. J Clin Endocrinol Metab. Jan. 1993;76(1):17-23.
Mihara et al. Cell cycle-dependent regulation of phosphorylation of the human retinoblastoma gene product. Science. Dec. 8, 1989;246(4935):1300-3.
Miki et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science. Oct. 7, 1994;266(5182):66-71.
Mitchell et al. Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Cancer Res. Dec. 1, 1999;59(23):5892-5.
Miyamoto and Chang, Antiandrogens fail to block androstenedione-mediated

Affiliated with

Also associated with

Rating

Androgen receptor coactivators does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Androgen receptor coactivators, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Androgen receptor coactivators will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3605180