And practical process for exclusively producing...

Organic compounds -- part of the class 532-570 series – Organic compounds – Chalcogen in the nitrogen containing substituent

Reexamination Certificate

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Details

Other Related Categories

C514S229800

Type

Reexamination Certificate

Status

active

Patent number

07964723

Description

ABSTRACT:
A novel and practical process for selectively producing a pyridobenzoxazine carboxylic acid hemihydrate (e.g., (S)-9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-[1,2,3-de] [1,4]benzoxazine-6-carboxylic acid hemihydrate) in high yield via crystallization from an organic solvent or a mixed organic solvent system containing a calculated amount of water released from sodium sulfate decahydrate under gradually heating.

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Kitaoka, H, et al., “Effect of Dehydration on the Formation of Levoflaxacin Pseudopolymorphs,” Chem. Pharm. Bull., (1995) 43(4): 649-653.
International Search Report for PCT/US2008/080740.

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