(+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-yl

Details (+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-yl (+) AND (-) 1-Methyl-4-(3-cyano-5H-dibenzo(a,d)-cyclohepten-5-yl

1976-01-27

1977-11-29

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

26029362, A61K 31445

Patent

active

040606228

ABSTRACT:
Resolution of 1-methyl-4-(3-cyano-5H-dibenzo-[a,d]-cyclohepten-5-ylidene)piperidine provides a levorotary isomer (-) having major tranquilizer pharmaceutical utility and a dextrorotary isomer (+) having anticholinergic pharmaceutical utility. Also disclosed are pharmaceutical compositions comprising either isomer substantially free of the other; pharmaceutical compositions comprising preferred ratios of the (+) and (-) isomers; and methods of treatment comprising administering such compounds and compositions.

REFERENCES:
patent: 3511881 (1970-05-01), Hoffsommer et al.
patent: 3547980 (1970-12-01), Engelhardt et al.
patent: 3960872 (1976-06-01), Prugh
patent: 3988342 (1976-10-01), Prugh
Ebnother et al., Helv. Chim. Acta. 1965, vol. 48, pp. 1237-1249.

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