Ancillary composition for the preparation of committed...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Reexamination Certificate

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C435S355000, C435S372000

Reexamination Certificate

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10466186

ABSTRACT:
The invention consists in the use of a maturation agent comprising a mixture of ribosomal and/or membrane fractions for the preparation of mature dendritic cells from immature dendritic cells.

REFERENCES:
patent: 2001/0026937 (2001-10-01), Punnonen et al.
patent: WO 99 47646 (1999-09-01), None
patent: WO 02/074939 (2002-09-01), None
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“Characterization of a functional property of MD-APCs according to the invention: Antibody Dependent Cell Cytotoxicity (ADCC) assay”, APC USA 09/194,053, priority EP 96 401 099.5, May 21, 1996.
Coronel, Agnes et al., “Cytokine production and T-cell activation by macrophage-dendritic cells generated for therapeutic use”, British Journal of Haematology, 2001, 114, pp. 671-680.
Tsuji et al::, “Maturation of Human Dendritic Cells by Cell Wall Skeleton of Mycobacterium Bovis Bacillus Calmette-Guerin: Involvement of Toll-Like Receptors”, Infection and Immunity, vol. 68, No. 12, - Dec. 2000, pp. 6883-6890, XP000995248, ***See abstract Materials and Methods, esp. p. 6884, RH column third paragraph, Results, Discussion*** the whole document.
Banchereau and Steinman: “Dentritic Cells and the Control of Immunity” Nature, vol. 392, Mar. 19, 1992, pp. 245-252, XP002134557 ***see whole document, especially ***p. 246, column 2, paragraph 2.
Revillard et al.:, “In Vitro Cell Activating Properties of the Composite Ribosomal Vaccine D53” Mem. Inst. Oswaldo Cruz, vol. 82, No. Suppl. II, 1987, pp. 173-178, XP000995084, Rio de Janeiro *** see whole document, especially *** p. 177, column 2, paragraph 1.
Caux et al.: “Gamma-Interferon Enhances Factor-Dependent Myeloid Proliferation of Human CD34+ Hematopoietic Progenitor Cells” Blood, vol. 79, No. 10, May 15, 1992, pp. 2628-2635, XP002043207, *** see entire document , especially *** p. 2629, column 2, paragraph 2 -p. 2630, column 2, paragraph 1.

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