Anatomical imaging with phycocyanins

Details Anatomical imaging with phycocyanins Anatomical imaging with phycocyanins

1996-04-09

1998-09-15

Kight, John

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

424 91, 424 94, 424 95, 424 96, 424 93, A61K 5100, A61M 3614

Patent

active

058075364

ABSTRACT:
Phycocyanins selectively impregnate biological structures including atherosclerotic plaque and tumors. Imaging of biological structures can be enhanced by tagging to a phycocyanin an atom which is compatible with the or complementary to any of the imaging modalities. The tagged phycocyanin can then be administered to a subject. The improvement can be utilized to enhance images of all structures, arterial wall thickness, atherosclerotic plaque, luminal boundaries and to better delineate tumors mass outlines.

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patent: 5489525 (1996-02-01), Pastan
Fuchs et al (1988), Am. Rev. Respir. Dis., vol. 138, No. 5, pp. 1124-1128, "Use of Allophycocyanin Allows Quantatitive Description by Flow Cytometry of Alveolar Macrophage Surface Antigens Present in Low Numbers of Cells".

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