Anatomic and functional imaging of tagged molecules in animals

Image analysis – Applications – Biomedical applications

Reexamination Certificate

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C382S129000, C382S130000, C382S131000, C382S132000, C382S133000, C382S134000

Reexamination Certificate

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10341715

ABSTRACT:
A novel functional imaging system for use in the imaging of unrestrained and non-anesthetized small animals or other subjects and a method for acquiring such images and further registering them with anatomical X-ray images previously or subsequently acquired. The apparatus comprises a combination of an IR laser profilometry system and gamma, PET and/or SPECT, imaging system, all mounted on a rotating gantry, that permits simultaneous acquisition of positional and orientational information and functional images of an unrestrained subject that are registered, i.e. integrated, using image processing software to produce a functional image of the subject without the use of restraints or anesthesia. The functional image thus obtained can be registered with a previously or subsequently obtained X-ray CT image of the subject. The use of the system described herein permits functional imaging of a subject in an unrestrained
on-anesthetized condition thereby reducing the stress on the subject and eliminating any potential interference with the functional testing that such stress might induce.

REFERENCES:
patent: 6490476 (2002-12-01), Townsend et al.
patent: 6666579 (2003-12-01), Jensen
patent: 2004/0002641 (2004-01-01), Sjogren et al.

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