Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-07-05
2011-07-05
Chung, Susannah (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S383000, C514S403000, C548S190000, C548S195000, C548S255000, C548S262200, C548S300100, C549S079000
Reexamination Certificate
active
07973061
ABSTRACT:
The present invention relates to compounds of the Formula I, wherein L, X, Y, Z, R1, R2, R3and R4are defined herein. The invention also provides methods of using the compounds for inhibition of kinases, more specifically ALK kinases. The invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinase receptor signal transduction pathways related to the changes in cellular activities as mentioned above, and the invention includes compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions; (Formula I).
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Leahy James William
Lewis Gary Lee
Nuss John M.
Ridgway Brain Hugh
Sangalang Joan C.
Chung Susannah
Exelixis Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
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