Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1985-04-15
1988-04-12
Marantz, Sidney
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 29, 4351722, 43524026, 435941, 436 63, 436172, 436503, 436519, 436821, 935 90, 935103, 935110, C12N 500, C12Q 102, G01N 33567, G01N 33569
Patent
active
047374551
ABSTRACT:
The property of phagocyte cells to show chemiluminescence when activated by certain chemical or immunological agents is used for a qualitative and quantitative analysis of such agents in biological fluids. A variety of factors such as opsonizing anti-bodies, complement, inhibitors, membrane-specific anti-bodies, and their antigens, membrane-specific lectins, lymphokines, endotoxins, toxic substances and others can be analyzed in this way. The new method finds application in the biotechnical, clinical, immunological and pharmacological fields, with a special preference for toxicological screening of pharmaceuticals. The phagocyte cells needed for the analysis can be derived from a continuous phagocyte cell line and a method of producing such a cell line is provided.
REFERENCES:
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E. Tzehoval et al., Journ. Immunology, 132, 1741-1747, 1984.
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V. G. Hemming et al., Journ. Clin. Invest. 58, 1379-1387, 1976.
C. R. Johnson et al., Journ. Immunol. Meth. 67, 108-117, 1984.
P. Stahl et al., Journ. Cell Biol. 93, 49-56, 1982.
E. Tzehoval et al., In S. J. Norman et al. (Eds.) Macrophages and Natural Killer Cells, Plenum Press, New York, pp. 445-451, 1982.
501 N.V. Innogenetics
Marantz Sidney
Saunders David A.
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