Analytical or clinical derivatives, tagged derivatives and metho

Details Analytical or clinical derivatives, tagged derivatives and metho Analytical or clinical derivatives, tagged derivatives and metho

1976-05-17

1978-09-19

Padgett, Benjamin R.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

260112R, 2602395, 260291, 424 12, A61K 4300, G01N 3300

Patent

active

041155394

ABSTRACT:
Novel isocyanates such as, for example, blocked L-tyrosine methyl ester isocyanate, are reacted with compounds of biological, clinical interest or the like such as, for example, digoxin, to form derivatives receptive to tagging, as by radiolabeling. The tagged derivatives may then be employed to determine the presence of the compound of interest in nanomolar or even picomolar amounts by using clinical analysis techniques such as radioimmunoassay.

REFERENCES:
patent: 3843696 (1974-10-01), Wagner et al.
patent: 3867366 (1975-02-01), Rubenstein et al.
patent: 3878187 (1975-04-01), Schneider et al.
patent: 3888866 (1975-06-01), Leute et al.
patent: 3953431 (1976-04-01), Rutner et al.
patent: 3996344 (1976-12-01), Gross

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