Analytical method for detecting alkaline sphingomyelinase...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving hydrolase

Reexamination Certificate

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Reexamination Certificate

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11712417

ABSTRACT:
An analytical fluorometric method and a kit for use in such method are disclosed for assessing the presence of alkaline sphingomyelinase (SMase) in the stool of a patient in need of such an assessment since alkaline SMase is a marker of serious pathological states, such as colon cancer.

REFERENCES:
patent: 6265179 (2001-07-01), Zhou et al.
patent: WO 03/056031 (2003-07-01), None
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“Amplex Red Sphingomyelinase Assay Kit (A12220)” Invitrogen/Molecular Probes Product Information, Revised, 4 pages (Oct. 2004).
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He et al. “A fluorescence-based, high-throughput sphingomyelin assay for the analysis of Niemann-Pick disease and other disorders of sphingomyelin metabolism.” Anal. Biochem. 306:115-123 (2002) Abstract.
Hertervig et al. “Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma” Cancer 79:448-453 (1997).
Sofic et al.“Antioxidant and pro-oxidant capacity of catecholamines and related compounds. Effects of hydrogen peroxide on glutathione and spingomyelinase activity in pheochromocytoma PC12 cells: Potential relevance to age-related diseases.” J. Neural Trans. 108:541-557 (2001).
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Int'l Search Report for Int'l Appln. No. PCT/IT02/00811 dated Oct. 10, 2003.

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