Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1996-10-25
1999-02-02
Smith, Lynette F.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435 721, 435 732, 435 6, C12Q 170, C12Q 168, G01N 3353, G01N 33554
Patent
active
058663215
ABSTRACT:
An analyte and a reactant 3 that reacts with the analyte either directly or indirectly are allowed to react with each other on the analytical areas A of a substrate 1 and signals originating from the reaction are detected. In at least a signal detection step, either a signal generation-related portion 4x or a detector is provided in a portion that is opposed to the substrate 1 and high and low areas are formed in either the substrate 1 or the opposed portion or both in such a manner that the distance from each analytical area A of the substrate to the opposed portion is shorter than the distance from each of the non-analytical areas B of the substrate to the opposed portion, whereby signals originating from the reaction in the analytical areas A will be detected at higher intensities than signals originating from the reaction in the non-analytical areas B. The analyte can be quantitatively or qualitatively analyzed on the analytical areas of the substrate in high precision with reduced effects from the non-analytical areas of the substrate. Simultaneous analysis of multiple samples or simultaneous analysis for multiple items can also be accomplished with a simple sensor configuration.
REFERENCES:
patent: 5514553 (1996-05-01), Simonson
"Detection of Microspotted Carcinoembryonic Antigen on a Glass Substrate by Scanning Electrochemical Microscopy," by Hitoshi Shiku, et al; Anal. Chem, 1996, 68, 1276-1278.
"Microfabrication and Characterization of Diaphorase-Patterned Surfaces by Scanning Electrochemical Microscopy", by Hitoshi Shiku et al., Anal. Chem. 1995, 67, 312-317.
"Chemical Imaging of Surfaces with the Scanning Electrochemical Microscope", by Allen J. Bard et al., Science, vol. 254, Oct. 4, 1991, 68-74.
"Application of Scanning Electrochemical Microscopy to Biological Samples," by Chongmok Lee et al., Proc. Natl. Acad. Sci. USA, vol. 87, pp. 1740-1743, Mar. 1990.
Matsue Tomokazu
Shiku Hitoshi
Uchida Isamu
Mochida Pharmaceutical Co. Ltd.
Smith Lynette F.
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