Analytical element having improved spreading zone and method of

Chemistry: analytical and immunological testing – Optical result – With reagent in absorbent or bibulous substrate

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422 56, 422 57, 435 15, 435 26, 435805, C12Q 132, C12Q 148, G01N 3352

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045474656

ABSTRACT:
A dry element capable of use for the analysis or transport of liquids comprises an isotropically porous zone which comprises a blush polymer having dispersed therein a particulate material and a nonpolymeric heterocyclic, aliphatic or carbocyclic quaternary ammonium compound comprising at least 12 carbon atoms therein. This compound is present in the porous zone in an amount of at least about 2 weight percent, based on the dry weight of the blush polymer. The porous zone of this element has improved cohesive strength which improves its resistance to abrasion. The element can be used to determine an analyte in an aqueous liquid, such as biological fluids.

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