Analytical device for the automated determination of analytes in

Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample

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435 14, 435810, 422 58, 422 91, 422104, 422 8205, 436 46, 356 39, 356 40, 364497, 128770, G01N 2100, G01N 3348, C12Q 154

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050593943

ABSTRACT:
A method for determining the presence of an analyte in a fluid is described along with various components of an apparatus specifically designed to carry out the method. The method involves taking a reflectance reading from one surface of an inert porous matrix impregnated with a reagent that will interact with the analyte to produce a light-absorbing reaction product when the fluid being analyzed is applied to another surface and migrates through the matrix to the surface being read. Reflectance measurements are made at two separate wavelengths in order to eliminate interferences, and a timing circuit is triggered by an initial decrease in reflectance by the wetting of the surface whose reflectance is being measured by the fluid which passes through the inert matrix. The method and apparatus are particularly suitable for the measurement of glucose levels in blood without requiring separation of red blood cells from serum or plasma.

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patent: 4637403 (1987-01-01), Garcia et al.
patent: 4717546 (1988-01-01), Barnett
patent: 4787398 (1988-11-01), Garcia et al.
N. Tietz (ed.), Textbook of Clinical Chemistry, (W. B. Saunders Philadelphia) pp. 267-269 (1986).
"Blood Glucose Monitors", in Health Devices, vol. 17, No. 9, pp. 253, 257-258 (Sep. 1988).

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