Analytical biosensor

Details Analytical biosensor Analytical biosensor

1995-03-03

1997-05-13

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

356445, 385 12, 385 36, 385129, 385130, 422 55, 422 58, 422 8205, 422 8211, 435 75, 4352871, 4352872, 4352879, 4352887, 435808, 436164, 436165, 436525, 436527, 436532, 436805, G01N 33543, G01N 33552, G01N 33547

Patent

active

056292139

ABSTRACT:
A biosensor for use in a surface plasmon resonance (SPR) System includes a transparent substrate layer, a thin metallic film on the substrate, and an ultrathin organic layer of a material which is polyanionic and adsorbs on the metallic film, and a layer of polylysine on this polyanionic material. In one embodiment, there is an outer layer on the polylysine which binds with a specific desired analyte.

REFERENCES:
patent: 4844613 (1989-07-01), Batchelder et al.
patent: 4877747 (1989-10-01), Stewart
patent: 5242828 (1993-09-01), Bergstrom et al.
patent: 5341215 (1994-08-01), Seher
patent: 5374563 (1994-12-01), Maule
patent: 5436161 (1995-07-01), Bergstrom et al.
Jordan, et al., "Characterization of Poly-L-lysine Adsorption onto Alkanethiol-Modified Gold Surfaces with Polarization-Modulation Fourier Transform Infrared Spectroscopy and Surface Plasmon Resonance Measurements", Dept. of Chemistry, UWM, Langmuir 1994, pp. 3642-43648.

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