Chemistry: analytical and immunological testing – Optical result – With fluorescence or luminescence
Reexamination Certificate
2006-05-16
2006-05-16
Ceperley, Mary E. (Department: 1641)
Chemistry: analytical and immunological testing
Optical result
With fluorescence or luminescence
C436S095000, C436S501000
Reexamination Certificate
active
07045361
ABSTRACT:
Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address the problem of obtaining fluorescence emission at wavelengths greater than about 500 nm. Biosensor molecules generally include an (1) an acridine-based fluorophore, (2) a linker moiety and (3) a boronate substrate recognition/binding moiety, which binds polyhydroxylate analytes, such as glucose. These biosensor molecules further include a “switch” element that is drawn from the electronic interactions among these submolecular components. This fluorescent switch is generally “off” in the absence of bound polyhydroxylate analyte and is generally “on” in the presence of bound polyhydroxylate analyte. Thus, the reversible binding of a polyhydroxylate analyte essentially turns the fluorescent switch “on” and “off”. This property of the biosensor molecules, as well as their ability to emit fluorescent light at greater than about 500 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
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Heiss Aaron M.
Noronha Glenn
Ponder Bill C.
Reilly Jonathan
Vachon David J.
Ceperley Mary E.
Gates & Cooper LLP
Medtronic MiniMed, Inc.
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