Analyte sensing mediated by adapter/carrier molecules

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C204S400000, C204S403060, C422S051000, C422S051000, C422S082010, C422S082050, C422S082070, C422S082080, C435S287100, C435S287200, C435S288700, C435S808000, C436S517000, C436S528000, C436S536000, C436S805000, C436S806000, C436S149000, C530S391100

Reexamination Certificate

active

06927070

ABSTRACT:
This invention relates to an improved method and system for sensing of one or more analytes. A host molecule, which serves as an adapter/carrier, is used to facilitate interaction between the analyte and the sensor element. A detectable signal is produced reflecting the identity and concentration of analyte present.

REFERENCES:
patent: 5252743 (1993-10-01), Barrett et al.
patent: 5620850 (1997-04-01), Bamdad et al.
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5817771 (1998-10-01), Bayley et al.
patent: 5824776 (1998-10-01), Bayley et al.
patent: 6083763 (2000-07-01), Balch
patent: WO 99/05167 (1999-02-01), None
Gu, L. et al., “Stochastic sensing of organic analytes by a pore-forming protein containing a molecular adapter,”Nature,vol. 398, pp. 686-690 (Apr. 1999).
Braha O., et al., “Designed protein pores as components for biosensors,”Chemistry&Biology, vol. 4, pp. 497-505 (Jul. 1997).
Kasianovicz, et al., “Characterization of individual polynucleotide molecules using a membrane channel,”Proc. Natl. Acad. Sci. USA, vol. 93, pp. 13770-13773 (Nov. 1996).
Krasilnikov, et al., “A simple method for the determination of the pore radius of ion channel sin planar lipid bilayer membranes,”FEMS Microbiology Immunology,vol. 105, pp. 93-100 (1992).
Beer, et al., “Molecular recognition of anions by synthetic receptors,”Current Opinion in Chemical Biology,vol. 1, pp. 475-482 (1997).
Chen, et al, “Recognition of neutral species with synthetic receptors,”Current Opinion in Chemical Biology, vol. 1, pp. 458-466 (1997).
Hellinga, et al., “Protein engineering and the development of generic biosensors,”Tibtech,vol. 16, pp. 183-189 (Apr. 1998).
Braha, et al., “Designated protein pores as components for biosensors,”Chemistry&Biology,vol. 4, No. 7, pp. 497-505 (1997).
Bianchet, et al., “The three-dimensional structure of bovine odorant binding protein and its mechanism of odor recognition,”Nature Structural Biology,vol. 3, No. 11, pp. 934-939 (Nov. 1996).
Xie, “Single-Molecule Spectroscopy and Dynamics at Room Temperature,”Acc. Chem. Res.,vol. 29, No. 12, pp. 598-606 (1996).
Hulteen, et al., “Introducing Chemical Transport Selectivity into Gold Nanotubule Membranes,”J. Am. Chem. Soc.,vol. 120, pp. 6603-6604 (1998).
Tabushi, et al., “A,B,D,F-Tetrasubstituted ÿ- Cyclodextrin as Artificial Channel Compound,”Tetrahedron Letters,vol. 23, No. 44, pp. 4601-4604 (1982).
Pregel, et al., “Towards Artificial Ion Channels: Transport of Alkali Metal Ions across Liposomal Membranes by “Bouquet” Molecules,”Angew. Chem. Int. Ed. Engl.,vol. 31, No. 12, pp. 1637-1639 (1992).
Odashima, et al., “Voltammetric Study on a Condensed Monolayer of a Long Alkyl Cyclodextrin Derivative as a Channel Mimetic Sensing Membrane,”Analytical Chemistry,vol. 65, No. 7, pp. 927-936 (Apr. 1, 1993).
Duax, et al., “Molecular Structure and Mechanisms of Action of Cyclie and Linear Ion Transport Antibiotics,”Biopolymers(Peptide Science), vol. 40, pp. 141-155 (1996).
Walker, et al., “Functional Expression of the ÿ- Hemolysin ofStaphylococcus aureusin IntactEscherichia coliand in Cell Lysates,”The Journal of Biological Chemistry,vol. 267, No. 15, pp. 10902-10909 (1982).
Bayley, “Building Doors into Cells,”Scientific American,pp. 62-67 (Sep. 1997).
Menestrina, “Ionic Channels Formed byStaphylococcus aureusAlpha-Toxin: Voltage-Dependent Inhibition by Divalent and Trivalent Cations,”J. Membrane Biol.,vol. 90, pp. 177-190 (1986).
Bhakdi, et al., “Staphylococcal ÿ- toxin: Oligomerization of hydrophilic monomers to form amphiphilic hexamers induced through contact with deoxycholate detergent micelles,”Proc. Natl. Acad. Sci. USA,vol. 78, No. 9, pp. 5475-5479 (Sep. 1981).
Doleman, et al., “Trends in odor intensity for human and electronic noses: Relative roles of odorant vapor pressure vs. molecularity specific odorant binding,”Proc. Natl. Acad. Sci. USA,vol. 95, pp. 5442-5447 (May 1998).
Czamik, “A sense for landmines,”Nature,vol. 394, pp. 417-418 (Jul. 30, 1998).
Oberhauser, et al., “The molecular elasticity of the extracellular matrix protein tenascin,”Nature,vol. 393, pp. 181-185 (May 14, 1998).
Cornell, et al., “A biosensor that uses ion-channel switches,”Nature,vol. 387, pp. 580-583 (Jun. 5, 1997).
Petosa, et al., “Crystal structure of the anthrax toxin protective antigen,”Nature,vol. 385, pp. 833-838 (Feb. 27, 1997).
Song, et al., “Structure of Staphylococcal ÿ- Hemolysin, a heptameric Transmembrane Pore,”Science,vol. 274, pp. 1859-1866 (Dec. 13, 1996).
Doyle, et al., “The Structure of the Potassium Channel: Molecular Basis of K+Conduction and Selectivity,”Science,vol. 280, pp. 69-77 (Apr. 3, 1998).
Sackmann, “Supported Membranes: Scientific and Practical Applications,”Science,vol. 271, pp. 43-48 (Jan. 5, 1996).
Hartgerink, et al., “Pept6ide Nanotubes and Beyond,”Chem. Eur. J.,vol. 4, No. 8, pp. 1367-1732 (1998).
Pregel, et al., “Channel-type Molecular Structures. Part 4. Transmembrane Transport of Alkali-metal Ions by ‘Bouquet’ Molecules,”J. Chem Soc. Perkin Trans.,vol. 12, pp. 417-426 (1995).
Heyse, et al., “Emerging techniques for investigating molecular interactions at lipid membranes,”Biochemica et Bioophysica Acta,85507, pp. 319-338 (1998).
Schuster, et al, “Self-assembled ÿ- hemolysin pores in an S-layer-supported lipid bilayer,”Bichimica et Biophysica Acta1370, pp. 280-288 (1998).
Gouaux, “ÿ- Hemolysin fromStaphylococcus aureus:An Archetype of ÿ- Barrel, Channel-Forming Toxins,”Journal of Structural Biology,vol. 121, pp. 110-122 (1998).
Schmid, et al., “Porin mutants with new channel properties,”Protein Science,vol. 7, pp. 1603-1611 (1998).
Bezrukov, et al., “Dynamics and Free Energy of Polymers Partitioning into a Nanoscale Pore,”Maromolecules,vol. 29, pp. 8517-8522 (1996).
Rekharsky, et al., “Complexation Thermodynamics of Cyclodextrins,”Chem. Rev.,vol. 98, pp. 1875-1917 (1998).
Ekin et al. (1991) Multianalytic microspot immunoassay-micoanalytical “compact disk” of the future. Clin. chem. 37(11): 1955-1966.
Fodor et al. (1993) Multiplexed biochemical assays with biological chips. Nature. 364:555-556.
He et al. (1997) Voltametric responsive sensors for organic compounds based on organized self-assembled lipoyl-b-cyclodextrin derivative monolayer on a gold electrode. Anal. Chim. Acta. 337:217-223.
Nagase et al. (1990). Voltammetric anion responsive sensors based on modulation of ion permeability through Langmuir-Blodgett films containing synthetic anion receptors. Anal. chem. 62:1252-1259.
Bugler et al. (1998). Novel water-soluble b-cyclodextrin-calix[4]arene couples as fluorescent sensor molecules for the detection of neutral analytes. J. Org. Chem. 63:5339-5344.
Kemeny (1997) Enzyme-linked immunoassays. In Immunochemistry 1, A Practical Approach (Eds. Johnstone et al.). New York: Oxford University Press, pp. 147-176.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Analyte sensing mediated by adapter/carrier molecules does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analyte sensing mediated by adapter/carrier molecules, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analyte sensing mediated by adapter/carrier molecules will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3462899

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.