Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Patent
1995-09-05
1997-12-09
Achutamurthy, Ponnathapura
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
435 71, 435 72, 435 74, 435 12, 435 18, 435 34, 435 39, 436183, 367157, C12Q 100, G01N 2918, G01N 3348, G01N 3353
Patent
active
056959257
ABSTRACT:
A composition is provided which is a transducing polymer having from 1 to 20 crosslinks per polymer molecule and selected from the group consisting of amphoteric co- or ter-polymers of pI between 6.2 to 8.0 of acrylic acid, alkyl methacrylate, and N,N-dimethly-aminoethyl methacrylate, the amphoteric co- or ter-polymer immobilized on a surface. Also provided is a method for the preparation of an analyte-responsive polymer immobilized on a surface in which the steps are a. mixing a solution of a crosslinker and the claimed transducing polymer, b. applying the solution of step a to a surface, and c. then curing the polymer to a ratio of from 1 to 20 crosslinks per transducing polymer molecule. Acoustic and optical methods for detecting analtyes are also provided which use an analyte-responsive polymer.
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Ebersole Richard Calvin
Foss Robert Paul
Ward Michael David
Achutamurthy Ponnathapura
E. I. Du Pont de Nemours and Company
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