Analyte detection

Details Analyte detection Analyte detection

1997-04-29

1999-10-12

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving diffusion or migration of antigen or antibody

422 8205, 422 8211, 435 6, 435 71, 4352872, 4352879, 4352887, 435808, 436164, 436501, 436524, 436525, 436527, 436528, 436529, 436805, 436807, 436824, 436 52, G01N 33543

Patent

active

059654562

ABSTRACT:
Disclosed is apparatus for detecting the presence of an analyte of interest in a sample, comprising an immobilised binding partner comprising a solid support and a reversibly binding receptor which is capable of binding to the analyte of interest thereby causing a measurable change in a property of the immobilised partner, and detection means for detecting the measurable change and a method for detecting the presence of an analyte of interest.

REFERENCES:
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Karlsson, et al: Kinetic analysis of monoclonal antibody-antigen interactions with a new biosensor based analytical system:, Journal of Immunological Methods, vol. 145, 1991, pp. 229-240.
Anderson, et al: "Fiber Optic Immunochemical Sensor for Continuous, Reversible Measurement of Phenytoin". Clinical Chemistry, vol. 34, No. 7, Jul. 1988, pp. 1417-1421.
Johnsson, et al: "Immobilization of Proteins to a Carboxymethyldextran-Modified Gold Surface for Biospecific Interaction Analysis in Surface Plasmon Resonance Sensors", Analytical Biochemistrym vol. 198, No. 2, Nov. 1991, pp. 268-277.
Altschuh, et al: "Determination of Kinetic Constants for the Interaction between a Monoclonal Antibody and Peptides using Surface Plasmon Resonance", Biochemistry, vol. 31, No. 27, Jul. 14, 1992, pp. 6298-6304.
Griffiths, "Human anti-self antibodies with high specifity fro phage display libraries", EMBO Journal, vol. 12, No. 2, Feb. 1993, pp. 725-734.
O'Shannessy, et al: "Immobilization Chemistries Suitable for Use in the BIAcore Surface Plasmon Resonance Detector", Analytical Biochemistry, vol. 205, No. 1, Aug. 15, 1992, pp. 132-136.

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