Analysis of temperature-dependent molecular configurations

Details Analysis of temperature-dependent molecular configurations Analysis of temperature-dependent molecular configurations

2008-05-13

2008-05-13

Porta, Dave (Department: 2884)

Radiant energy

Invisible radiant energy responsive electric signalling

Ultraviolet light responsive means

C250S341100

Reexamination Certificate

active

10493402

ABSTRACT:
An apparatus and method for analysing temperature-dependent molecular configurations such as folding comprises a multi-channel flow-through chip (12) along which molecules to be analysed pass. A temperature gradient is maintained along the length of the chip. As molecules pass along the channels they fold or unfold, in response to the changing temperature. These changing molecular configurations are investigated by simultaneously measuring the extent to which the molecules absorb UV light, and the extent to which they fluoresce. The absorption and fluorescence information is supplied to a computer system (26) for real-time analysis.

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