Chemistry: electrical and wave energy – Processes and products – Electrostatic field or electrical discharge
Patent
1992-04-17
1993-04-13
Niebling, John
Chemistry: electrical and wave energy
Processes and products
Electrostatic field or electrical discharge
204299R, G01N 27447, G01N 2726, B01D 5702
Patent
active
052020061
ABSTRACT:
Disclosed herein are buffers and methodologies for the capillary zone electrophoretic analysis of hemoglobin and the variants of hemoglobin. In a particularly preferred embodiment, the buffer comprises at least about 100 mM of barbituric acid, derivatives of barbituric acid, combinations of barbituric acid and the derivatives of barbituric acid, and combinations of the derivatives of barbituric acid, and has a pH of at least about 8.0.
REFERENCES:
Chen, Fu-Tai, et al., "Capillary Electrophoresis-a New Clinical Tool", Clin. Chem. 37/1:14-19 (1991).
Beckman Instructions 015-245302-F "Paragon.sup.R Hemoglobin Electrophoresis Kit", P/N 441780 (1988).
Zhu, M., et al. "Optimizing separating parameters in capilary isoelectric focusing", O. Chrom. 559:479-488 (1991).
Zhu, M. et al., "Capilliary Electrohporesis of Hemoglobins and Globin Chains", 4th Internatl. Symposium. . . Feb. 9-13, 1992 . . .
Electrophoresis & Immunoelectrophoresis, Leo P. Cawley, M.D. Little, Brown & Co., Boston, Mass. 1969 Chpt. 10 "Hemoglobinopathies".
Beckman Bulletin 6223. Paragon.sup.R Electrophoresis System 1991.
Beckman Bulletin 6234. The Appraise.sup.R and Paragon.sup.R Electrophoresis Systems (1991).
Beckman Bulletin EP-5 Macy, J. "Hemoglobin Electrophoresis Applications Guide" (1986).
Beckman Bulletin EP-8 Wild, B. J., "Abnormal Hemoglobins Applications Guide" (1988).
Ming-De Zhu et al "Carrier-Free Zone Electrophoresis, Displacement Electrophoresis and Isoelectric Focusing in a High-Performance Electrophoresis Apparatus" Journal of Chromatography 403(1987) 47-61.
Chin-Tiao Wu, Teresa Lopes, Bhisma Patel, and Cheng S. Lee "Effect of Direct Control of Electroosmosis on Peptide and Protein Separations in Capillary Electrophoresis" Analytical Chemistry 64 (1992) 886-891.
Mingde Zhu, David L. Hansen, Sam Burd, & Frank Gannon, "Factors Affecting Free Zone Electrophoresis and Isoelectric Focusing in Capillary Electrophoreis" Journal of Chromatography 480 (1989) 311-319.
Beckman Instruments Inc.
Grant Arnold
May William H.
Niebling John
Starsiak Jr. John S.
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