Analysis of biological targets using a biochip comprising a...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C536S024300, C536S025200, C536S026600, C435S006120

Reexamination Certificate

active

06861515

ABSTRACT:
This invention relates to an analytical support containing a plurality of oligonucleotides fixed on this support, where each of the nucleotides is marked by a fluorescent compound that presents a variation of fluorescence on the hybridization of each marked oligonucleotide with at complementary oligonucleotide. This support makes it possible to carry out an analysis of biological targets by measuring the variation of fluorescence in order to determine the hybridization of the targets with the oligonucleotides of the support.

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J. Yguerabide et al.: “Pyrene-labeled DNA probes for homogenous detection of complementary DNA sequences: Poly (C) model system” Analytical Biochemistry, vol. 241, No. 2, pp. 238-247 Oct. 15, 1996.
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