Electricity: measuring and testing – Particle precession resonance
Patent
1982-06-16
1984-10-16
Tokar, Michael J.
Electricity: measuring and testing
Particle precession resonance
324307, G01R 3308
Patent
active
044777779
ABSTRACT:
A method of determining or imaging fats in a non .sup.13 C enriched biological sample, particularly human tissue comprising subjecting the sample to a magnetic field, irradiating the sample with radiofrequency electromagnetic radiation, obtaining from the sample an electrical signal indicative of the radiofrequency absorption of the sample in the magnetic field at a frequency corresponding to the .sup.13 C NMR resonance frequency for --(CH.sub.2).sub.n --, filtering the signal to exclude components due to absorption by the sample attributable to carbon atoms other than those present as --(CH.sub.2).sub.n -- and determining from the intensity of the absorption the fat content of the sample, or applying to the signal an imaging technique to determine the fat distribution in the sample. .sup.1 H decoupling is preferably employed to increase signal-to-noise ratio.
The method is useful in the diagnosis of certain fat-related diseases, such as muscular dystrophy.
REFERENCES:
Peter Styles et al., Simultaneous Multinuclear NMR by Alternate Scan Recording of 31P and 13C Spectra, Journal of Magnetic Resonance 35, 329-336, (1979).
Gregory et al., Application of Wide-Line NMR to Analysis of Mineral Products and Fats and Oils, Journal of the American Oil Chemists Society, pp. 775-777, Sep. 1968.
W. Moniz, Carbon-13 Fourier Transform NMR-an Important New Analysis Tool, Report of NRL Progress, pp. 1-14, Aug. 1975.
Oxford Research Systems Limited
Tokar Michael J.
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