Analysis method for substance

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...

Reexamination Certificate

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C436S524000, C436S525000

Reexamination Certificate

active

11716553

ABSTRACT:
A method for analyzing a substance, comprising: a step of obtaining a dispersion complex by co-existing fine particles having a dispersion property higher than that of lyophobic fine particles in a dispersion phase of the lyophobic fine particles at a concentration sufficient for covering a periphery of a lyophobic fine particle group; a step of contacting the dispersion complex and a fluid containing an analyte; and a step of analyzing the analyte using an optical measuring means, wherein the lyophobic fine particles exist in the dispersion phase in a group for providing the surface enhancing effect. The method is effective for analysis of a slight amount substance or a low concentration substance.

REFERENCES:
patent: 9-70527 (1997-03-01), None
patent: 11-61209 (1999-05-01), None
Keitaro Nakamura et al., “Preparation of Gold-Clay Coexisting Gel and its Properties of Surface-enhanced Raman Scattering,” The autumnal workshop proceedings 1999 of the Society of Powder Technology, Japan, 44 (1999).
Keitaro Nakamura et al., “The Preparation of the Gold and Clay Coexisting Gel and its Properties of Surface-enhanced Raman Scattering,” (English translation of “Kin . Nendo Kyouzon Gel tai No Chousei to Hyomen Zoukyou Raman Sanran Tokusei”), The autumnal workshop proceedings 2000 of the Society of Powder Technology, Japan, pp. 44-46 (2000).
Chang, R. et al., “Surface Enhanced Raman Scattering,” Plenum Press, New York and London, pp. 109, 126-127 (1982).
Kneipp, K. et al., “Surface-enhanced Raman scattering: a new tool for biomedical spectroscopy,” Current Science, vol. 77, No. 7, pp. 915-924 (1999).
Kneipp, K. et al., “Extremely Large Enhancement Factors in Surface-Enhanced Raman Scattering for Molecules in Colloidal Gold Clusters,” Soc. for Applied Spectroscopy, vol. 52, No. 12, pp. 1493-1497 (1998).
Hayat, M.A., “Colloidal Gold—Principles, Methods, and Applications [Methods for Synthesis of Colloidal Gold by Dean A. Handley],” Academic Press, Inc., San Diego, California, pp. 13-32 (1989).
Khlebtsov, N. et al., “Spectral Extinction of Colloidal Gold and its Biospecific Conjugates,” Journal of Colloid and Interface Science, vol. 180, Article 0323, pp. 436-445 (1996).
Akbarian, F. et al., “Porous Sol-Gel Silicates Containing Gold Particles as Matrices for Surface-Enhanced Raman Spectroscopy,” Journal of Raman Spectroscopy, vol. 27, pp. 775-783 (1996).

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