Analysis and use of PAR1 polymorphisms for evaluating the...

Details Analysis and use of PAR1 polymorphisms for evaluating the... Analysis and use of PAR1 polymorphisms for evaluating the...

2011-02-22

2011-02-22

Sitton, Jehanne S (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

07892744

ABSTRACT:
The invention relates to polynucleotide sequences comprising genetic variations of the PAR1 gene at positions 3090 and/or 3329. The occurrence of these variants in humans correlates with increased occurrence of particular cardiovascular disorders. The invention furthermore relates to methods for detecting said genetic variations for the purpose of patient diagnosis.

REFERENCES:
patent: 5744338 (1998-04-01), Hodgson et al.
patent: 6316196 (2001-11-01), Morten
Cambien et al; American Journal of Human Genetics, vol. 65, pp. 183-191; 1999.
Arnaud, Emmanuel et al., Protective Effect of a Thrombin Receptor (Protease-Activated Receptor 1) Gene Polymorphism Toward Venous Thromboembolism, Arterioscler Thromb Vasc Biol., (2000), vol. 20. pp. 585-592.
Schmidt, Valentina A. et al. Genomic Cloning and Characterization of the Human Thrombin Receptor Gene, The Journal Of Biological Chemistry, (1996), vol. 271, No. 16, pp. 9307-9312.
Dupont, Annabelle et al., An intronic polymorphism in the PAR-1 gene is associated with platelet receptor denisty and the response to SFLLRN, Blood, (2003), vol. 101, pp. 1833-1840.
Park, H-Y et al, Identification of New Single-Nucleotide Polymorphisms In The Thrombin Receptor Gene And Their Effects on Coronary Artery Diseases In Koreans. Clinical and Experimental Pharmacology and Physiology, (2000), vol. 27. pp. 690-693.
Schmidt et al., Genbank Accession No. NM—001992 (Oct. 1999).
Cambien et al., Sequence Diversity in 36 Candidate Genes for Cardiovascular Disorders, Am J. Hum Genet., vol. 65, pp. 183-191, 1999.

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