Analogues of morpholinyl daunorubicin and morpholinyl doxorubici

Details Analogues of morpholinyl daunorubicin and morpholinyl doxorubici Analogues of morpholinyl daunorubicin and morpholinyl doxorubici

1983-05-24

1984-08-07

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1524

Patent

active

044645295

ABSTRACT:
A group of new daunorubicin and doxorubicin derivatives is disclosed. These materials have the formula ##STR1## wherein R is CO--CH.sub.3 or CHOH--CH.sub.3 in the case of daunorubicin derivatives or CO--CH.sub.2 OH or CHOH--CH.sub.2 OH in the case of doxorubicin derivatives; X is O or NH; and A is either a cyano group (CN) or a hydrogen, subject to the limitation that when X is O, A must be a cyano group. When A is hydrogen, these compounds can exist as acid addition salts, as well. Derivatives of these compounds are disclosed as well.

REFERENCES:
patent: 4109076 (1978-08-01), Henry et al.
patent: 4301277 (1981-11-01), Acton et al.

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