Analogues of morpholinyl daunorubicin and morpholinyl doxorubici

Details Analogues of morpholinyl daunorubicin and morpholinyl doxorubici Analogues of morpholinyl daunorubicin and morpholinyl doxorubici

1984-04-09

1986-04-29

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C07H 1524

Patent

active

045858594

ABSTRACT:
A group of new daunorubicin and doxorubicin derivatives is disclosed. Included in this group are 3'-deamino-3'(3"-cyano-4"-morpholinyl doxorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-13-dihydoxorubicin; (3'-deamino-3'-(3"-cyano-4"-morpholinyl) daunorubicin; 3'-deamino-3'-(3"-cyano-4"-morpholinyl)-3-dihydrodaunorubicin; and 3'-deamino-3'-(4"-morpholinyl-5-iminodoxorubicin and derivatives thereof which have excellent activity as antitumor agents.

REFERENCES:
patent: 4202967 (1980-05-01), Tong et al.
patent: 4301277 (1981-11-01), Acton et al.
patent: 4314054 (1982-02-01), Acton et al.
patent: 4464529 (1984-08-01), Mosher et al.

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