Analogues of magainin peptides containing D-amino acids

Details Analogues of magainin peptides containing D-amino acids Analogues of magainin peptides containing D-amino acids

1994-11-17

1998-08-11

Lukton, David

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

514 13, 514 14, A61K 3816

Patent

active

057928312

ABSTRACT:
Biologically active analogues of magainin peptides wherein each amino acid residue of the peptide is a D-amino acid residue or a glycine residue. Examples of such peptides wherein each amino acid residue is a D-amino acid residue or a glycine residue include deletion and substitution analogues of magainin peptides. Such peptides have increased resistance to proteolytic enzymes while retaining biological activity.

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