Analogues of lipopolysaccharide-binding protein...

Details Analogues of lipopolysaccharide-binding protein... Analogues of lipopolysaccharide-binding protein...

2006-03-14

2006-03-14

Navarro, Mark (Department: 1645)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S323000, C530S326000, C530S327000

Reexamination Certificate

active

07012127

ABSTRACT:
The present invention relates to analogues of peptides from lipopolysaccharide-binding protein (LBP) region whose primary sequence have been substituted at particular amino acid sites to obtain effective binding to, and neutralization of, lipopolysaccharide (LPS).

REFERENCES:
patent: 5731415 (1998-03-01), Gazzano-Santoro et al.
patent: WO 95/00641 (1995-01-01), None
patent: WO 95/05393 (1995-02-01), None
patent: WO 95/08560 (1995-03-01), None
patent: WO 95/25117 (1995-09-01), None
Accession No. AAW40153 sequence alingment.
Norbert Lamping, et al., “Effects of Site-Directed Mutagenesis of Basic Residues (Arg 94, Lys 95, Lys 99) of Lipopolysaccharide (LPS)-Binding Protein on Binding and Transfer of LPS and Subsequent Immune Cell Activation”,The Journal of Immunology, vol. 157, pp. 4648-4656 (1996).
Manuel J. Araña, et al., “Molecules Modulating Immune/Inflammatory Responses, Design and Development of Potential Therapeutics”,Biotecnologia Applicada, vol. 12, No. 2, pp. 101-102 (1995).

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