Analogues of acetylsalicylic acid and novel uses thereof

Details Analogues of acetylsalicylic acid and novel uses thereof Analogues of acetylsalicylic acid and novel uses thereof

1995-01-31

1997-02-04

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Fatty compounds having an acid moiety which contains the...

554229, 560 76, 560143, 560163, 568 28, 568 31, 568 25, 568425, 568630, 564123, 564192, 562405, 562477, 562478, C07C23300

Patent

active

055999590

ABSTRACT:
The present invention provides a salicylate analogue having the structure ##STR1## wherein R is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl; pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, phenyl, naphthyl and cyclohexyl; wherein R1 is selected from the group consisting of hydrogen, a C1-C12 alkyl group, F, Cl, Br, I, CO.sub.2 H, CONHR, CONR.sub.2, CO.sub.2 R, C.tbd.N, CHO, COR, SO.sub.3, SO.sub.2 NHR, SO.sub.2 NR.sub.2, OH, OR, OCOR, SH, SR, OCONHR, OCONR.sub.2, SCOR, SCONHR, SCONR.sub.2 and NH2, NHR, NHCOR and NR2; and wherein R1 is in the 3-, 4-, 5- or 6-position, or a combination thereof. Also provided are various pharmaceutical compositions of the novel compounds of the present invention.

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Covello et al, Chemical Abstracts, vol. 67, #13, 1967 63992.
Chemical Abstracts, vol. 53, #15, 14432a, 1959.
Reyes et al, Chemical Abstracts, vol. 101, #1, 1984.
Inoue et al, JP. J. Pharm., vol. 30, pp. 529-535, 1980.

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