Analogs of tyrosine sulfate or tyrosine phosphate containing pep

Details Analogs of tyrosine sulfate or tyrosine phosphate containing pep Analogs of tyrosine sulfate or tyrosine phosphate containing pep

1993-12-17

1996-04-16

Springer, David B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

560 27, 560 33, 560 37, C07D20736, C07C22934

Patent

active

055084370

ABSTRACT:
Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount of CCK analog wherein one or more of any Tyrosine Sulfate present is substituted with a radical of the invention.

REFERENCES:
patent: 5055481 (1991-10-01), Inukai et al.
Bodanszky et al., J. Med. Chem. 21, 1030-1035 (1978).
Marseigne, et al., Journal of Medicinal Chemistry, 32:445 (1989).
Wanner et al., Journal of Medicinal Chemistry, 23:85 (1980).
Yuki et al., Chem. Pharm. Bull. 19 (8) pp. 1664-1668 (1971).
Cleland, Journal of Organic Chemistry 34(3) pp. 744-747 (1969).
Caldwell, et al., J.C.S. Perkin I, 2 pp. 495-505 (1980).
Rudinger, Peptide Hormones, Parsons (Ed) J. Park Press. Baltimore, pp. 1-7 (1976).
Bergeson et al., Chem. Abstract vol. 105 No. 209396q (1986).

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