Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-12-05
2006-12-05
Owens, Amelia A. (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S164000, C546S284100, C544S335000
Reexamination Certificate
active
07145021
ABSTRACT:
The subject invention provides compounds having the structure:wherein R1is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; R2is H, OH, a photoactivatable moiety, a fluorescent-moiety, or a radioactive moiety; R3is H or OH; R4is H, OH, a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety; and wherein at least one of R1, R2, R3, or R4is a photoactivatable moiety, a fluorescent moiety, or a radioactive moiety, or an optically pure enantiomer of the compound or wherein R1 is H or OH; R2 is H, OH, halogen, unsubstituted or substituted, straight or branched (C1–C5) alkyl group, (C2–C5) alkenyl, or a (C2–C5) alkynyl, (C1–C5) alkoxy, (C2–C5) alkenyloxy, or (C2–C5) alkynyloxy, —N3, —COR5, —CONR5R6, —CO2R5, —OCOR5, —NH(OH), —NR5R6, —NHCOR5, —N(OH)COR5, —CH2OR5, —OCH2CO2R5, —CH2SR5, —CH2NR5R6, —SR5, —OSR5, or —NR5SO2R6, where R5 and R6 are each independently hydrogen, substituted or unsubstituted (C1–C5) alkyl, (C2–C5) alkenyl, or (C2–C5) alkynyl, or a cycloalkyl or aryl group having 3 to 10 carbon atoms; R3 is H or OH; R4 is H, (C1–C10) alkyl, (C1–C10) alkenyl, (C1–C10) alkynyl, -A-Ar, -A-Z-Ar, —SO2—Ar, or -A-NR5, or —R7, where A, Z and Ar are as defined herein, and the use of the compounds for detecting or identifying a receptor which binds the compounds of the invention or for treating a PAF associated condition in a subject.
REFERENCES:
patent: 5466829 (1995-11-01), Park et al.
patent: 5541183 (1996-07-01), Park et al.
patent: 5599950 (1997-02-01), Teng
patent: 6143725 (2000-11-01), Vasella
patent: 6187314 (2001-02-01), Xie et al.
patent: 6221356 (2001-04-01), Junsheng
patent: 6590109 (2003-07-01), Lichtblau et al.
patent: 6693091 (2004-02-01), Stromgaard et al.
patent: 6844451 (2005-01-01), Lichtblau et al.
patent: 2288599 (1995-10-01), None
patent: WO9952911 (1999-10-01), None
patent: WO 006040 (2003-01-01), None
patent: WO 03/082185 (2003-10-01), None
McKenna, Efficacy, safety, and use ofGinkgo bilobain clinical and preclinical applications, PMID: 11565403, (2001).
Corey, E. J. & Su, W. G. (1987)J. Am. Chem. Soc.109, 7534-7536.
Corey, E. J., Kang, M. C., Desai, M. C., Ghosh, A. K., & Houpis, I. N. (1988)J. Am. Chem. Soc.110, 649-651.
Corey, E. J. & Ghosh, A. K. (1988)Tetrahedron Lett.. 29, 3205-3206.
Corey, E.J. & Gavai, A.V. (1989)Tetrahedron Lett. 306959-6962.
Corey, E.J. & Rao, K. S. (1991)Tetrahedron Lett. 324623-4626.
Hu, L., Chen, Z., Cheng, X., & Xie, Y. (1999)Pure Appl. Chem.71, 1153-1156.
Hu, L., Chen, Z., Xie, Y., Jiang , H., & Zhen, H. (2000)Bioorg. Med. Chem.8, 1515-1521.
Hu, L., Chen, Z., Xie, Y., Jiang , Y., & Zhen, H. (2000)J. Asian Nat. Prod. Res.2, 103-110.
Hu, L., Chen, Z., & Xie, Y. (2001)J. Asian Nat. Prod. Res.3, 219-227.
Jaracz et al. “Ginkgolides: Selective Acetylations, Translactonization, and Biological Evaluation”, J. Org. Chem 67(13):4623-4626 (2002).
Nakanishi Koji
Stromgaard Kristian
Suehiro Makiko
Vogensen Stine B.
Cooper & Dunham LLP
Owens Amelia A.
The Trustees of Columbia University in the City of New York
White John P.
LandOfFree
Analogs of terpene trilactones from Ginkgo biloba and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Analogs of terpene trilactones from Ginkgo biloba and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analogs of terpene trilactones from Ginkgo biloba and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3714302