Analogs of peptide YY and uses thereof

Details Analogs of peptide YY and uses thereof Analogs of peptide YY and uses thereof

1994-10-24

1997-02-18

Scheiner, Toni R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 514 14, 514 15, 514 16, 514 17, 530324, 530325, 530326, 530327, 530328, 530329, A61K 3800, C07K 500, C07K 700, C07K 1700

Patent

active

056042035

ABSTRACT:
The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion.

REFERENCES:
patent: 5026685 (1991-06-01), Boublik et al.
Balasubramaniam et al., "Structure-Activity Studies of Peptides YY(22-36): N-.alpha.-Ac-[Phe.sup.27 ]PYY(22-36), a Potent Antisecretory Peptide in Rat Jejunum;" Peptides 14:1011-1016, 1993.
Balasubramaniam et al., "Syntheses and Receptor Affinities of Partial Sequences of Peptide YY (PYY);" Peptide Research 1:32-35, 1988.
Feinstein et al., "Structural Requirements for Neuropeptide Y.sup.18-36 -Evoked Hypotension: A Systematic Study;" J. Med. Chem. 35:2836-2843, 1992.
Ishiguro et al., "Synthesis of Peptide Fragments of Neuropeptide Y: Potent Inhibitors of Calmodulin-Stimulated Phosphodiesterase;" Chem. Pharm. Bull. 36:2720-2723, 1988.
Lundberg et al., "Localization of Peptide YY (PYY) in Gastrointestinal Endocrine Cells and Effects on Intestinal Blood Flow and Motility;" Proc. Natl. Acad. Sci. USA 79:4471-4475, 1982.
Servin et al., "Peptides-YY and Neuropeptide-Y Inhibit Vasoactive Intestinal Peptide-Stimulated Adenosine 3', 5'-Monophosphate Production in Rat Small Intestine: . . . ;"Endocrinology 124:692-700, 1989.
Tatemoto "Isolation and Characterization of Peptide YY (PYY), a Candidate Gut Hormone that Inhibits Pancreatic Exocrine Secretion;" Proc. Natl. Acad. Sci. USA 79:2514-2518, 1982.
Voisin et al., "Characterization, Signal Transduction, and Expression during Cell Differentiation;" New York Academy of Sciences 611:343-346, 1990.
Balasubramaniam et al., "Synthesis, Receptor Affinities and Antisecretory Effects of Peptide YY (22-36) Analogs", presented at the Twelfth American Peptide Symposium, Jun. 16-21, 1991 in Cambridge, Massachusetts.

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