Analogs of parathyroid hormone

Details Analogs of parathyroid hormone Analogs of parathyroid hormone

2005-07-26

2005-07-26

Russel, Jeffrey Edwin (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000

Reexamination Certificate

active

06921750

ABSTRACT:
The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pharmaceutical compositions comprising said analogues alone or in combination with a bisphosphonate or calcitonin.

REFERENCES:
patent: 4656250 (1987-04-01), Morita et al.
patent: 5434246 (1995-07-01), Fukuda et al.
patent: 5455329 (1995-10-01), Wingender et al.
patent: 5457047 (1995-10-01), Wingender et al.
patent: 5589452 (1996-12-01), Krstenansky et al.
patent: 5599792 (1997-02-01), Kronis et al.
patent: 5723577 (1998-03-01), Dong
patent: 5955574 (1999-09-01), Dong
patent: 5969095 (1999-10-01), Dong
patent: 6544949 (2003-04-01), Dong
patent: 64834/96 (1999-07-01), None
patent: 0 293 158 (1988-11-01), None
patent: 451867 (1991-10-01), None
patent: 0 561 412 (1993-09-01), None
patent: 748817 (1996-12-01), None
patent: 2269176 (1994-02-01), None
patent: P9500110 (1995-06-01), None
patent: P9500115 (1995-06-01), None
patent: 217 843 (1995-09-01), None
patent: WO 90/10067 (1990-09-01), None
patent: WO 93/06846 (1993-04-01), None
patent: 94/01460 (1994-01-01), None
patent: 94/02510 (1994-02-01), None
patent: WO95/02610 (1995-01-01), None
patent: 95/04752 (1995-02-01), None
patent: 96/19246 (1996-06-01), None
patent: 96/40775 (1996-12-01), None
patent: 97/02834 (1997-01-01), None
Chorev et al., “Modifications of Position 12 in Parathyroid Hormone . . . ”, Bochemistry, vol. 29, No. 6, pp. 1580-1586 (1990).
Lynn H. Caporale et al.; “Characterization of parathyroid hormone antagonists” Peptides, Chemistry and Biology; Proceedings of the Tenth American Peptide Symposium; (1987); pp. 449-451.
Horiuchi N. et al.; “Similarity of synthetic peptide from human tumor to parathyroid hormone in vivo and in vitro” Science; (1987); vol. 238 pp. 1566-1568.
Gardella, T.J. et al.; “Parathyroid Hormone (PTH)-PTH-Related Peptide Hybrid Peptides Reveal Functional Interactions Between The 1-14 and 15 34 Domains of the Ligand”; J. Biol. Chem., vol. 270, No 12, pp 6584-6588, (1995).
Barden et al.,; “NMR Solution Structure of Human Parathyroid Hormone (1-34)”; Biochemistry 32:7126-7132; (1993).
Cohen et al.; “Analogues of Parathyroid Hormone Modified at Positions 3 and 6”; The Journal of Biological Chemistry 266:No. 3;1997-2004; (1991).
Karle et al.; “Structural Characteristics of α-Helical Peptide Molecules Containing Aib Residues”; Biochemistry 29:No. 29;6747-6756; (1990).
Leaffer et al.; Modulation of Osteogenic Cell Ultrastructure by RS-23581; an Analog of Human Parathyroid Hormone (PTH)-Related Peptide-(1-34), and Bovine PTH-(1-34); Endocrinology 136:No. 8;3624-3631, (1995).
Li et al.; “A Measure of Helical Propensity for Amino Acids in Membrane Environments”; Structural Biology 1:No. 6;368-373; (1994).
McLean et al.; “Minimal Peptide Length for Interaction of Amphipathic α-Helical Peptides with Phosphatidylcholine Liposomes”; Biochemistry 30:31-37; (1991).
Neugebauer et al.; “Structural Elements of Human Parathyroid Hormone and Their Possible Relation to Biological Activities”; Biochemistry 31:2056-2063; (1992).
Strickland et al.; “Structure of Human Parathyroid Hormone (1-34) in the Presence of Solvents and Micelles”; Biochemistry 32:6050-6057; (1993).
Surewicz et al.; “Structure-function Relationships in Human Parathyriod Hormone: The Essential Role of Amphiphilic α-Helix”; Peptide Hormone: 556-558 (not dated).

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