Analogs of parathyroid hormone

Details Analogs of parathyroid hormone Analogs of parathyroid hormone

1997-03-07

1999-09-21

Russel, Jeffrey E.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

25 or more amino acid residues in defined sequence

514 12, A61K 3829, C07K 14635

Patent

active

059555742

ABSTRACT:
Peptide variants of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), in which at least one of the amino acid residues is replaced with Acc.

REFERENCES:
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patent: 5434246 (1995-07-01), Fukuda et al.
patent: 5599792 (1997-02-01), Kronis et al.
patent: 5723577 (1998-03-01), Dong
Barden et al., "NMR Solution Structure of Human Parathyroid Hormone (1-34 Biochemistry 32:7126-7132, 1993.
Cohen et al., "Analogues of Parathyroid Hormone Modified at Positions 3 and 6", The Journal of Biological Chemistry 266:1997-2004, 1991.
Karle et al., "Structural Characteristics of .alpha.-Helical Peptide Molecules Containing Aib Residues", Biochemistry 29:6747-6756, 1990.
Leaffer et al., "Modulation of Osteogenic Cell Ultrastructure by RS-23581, an Analog of Human Parathyroid Hormone (PTH)-Related Peptide-(1-34), and Bovine PTH-(1-34)", Endocrinology 136:3624-3631, 1995.
Li et al., "A Measure of Helical Propensity for Amino Acids in Membrane Environments", Structural Biology 1:368-373, 1994.
McLean et al., "Minimal Peptide Length for Interaction of Amphipathic .alpha.-Helical Peptides with Phosphatidylcholine Liposomes", Biochemistry 30:31-37, 1991.
Neugebauer et al., "Structural Elements of Human Parathyroid Hormone and Their Possible Relation to Biological Activities", Biochemistry 31:2056-2063, 1992.
Strickland et al., "Structure of Human Parathyroid Hormone (1-34) in the Presence of Solvents and Micelles", Biochemistry 32;6050-6057, 1993.
Surewicz et al., "Structure-function Relationships in Human Parathyroid Hormone: The essential role of Amphiphilic .alpha.-Helix", Peptide Hormones 556-558, not dated.
Chorev, et al., "Modification of Position 12 in Parathyroid Hormone and Parathyroid Hormone Related Protein" Biochemistry, (1990) vol. 29, No. 6, pp. 1580-1586.
Caprole, Lynn H., et al., "Characterization of Parathyroid Hormone Antagonists", in "Peptides, Chemistry and Biology: Proceedings 10th American Peptide Symposium, St. Louis, 1987", Marshall, G.M. (Ed.), pp. 449-451 (1988).
Horiuchi, N., et al., "Similarity of Synthetic Peptide From Human Tumor To Parathyroid Hormone In Vivo and In Vitro", Science, vol. 238, pp. 1566-1568, 1987.
Gardella, T.J., et a: "Parathyroid Hormone (PTH)-PTH-Related Peptide Hybrid Peptides Reveal Functional Interactions Between The 1-14 and 15-34 Domains of the Ligand", J. Biol. Chem., vol. 270, No. 12, pp. 6584-6588, 1995.

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