Analogs of oxetanyl purines and pyrimidines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514212, 540542, 540601, 544232, 544310, 544316, 544317, A61K 31495, C07D23902, C07D40300, C07F 902

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active

055978240

ABSTRACT:
A compound of the formula: ##STR1## wherein B is a purin-9-yl group or a heterocyclic isostere of a purin-9-yl group; or a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; A is --CH-- or A--G taken together is --C(.dbd.O)--, --C(.dbd.CH.sub.2)--, --C(OH)(CH.sub.2 OH)-- or ##STR2## and G and D are functional groups; or a pharmaceutically acceptable salt or ester thereof.

REFERENCES:
patent: 4845215 (1989-07-01), Shimada et al.
Norbeck, Abstracts of 4th Cyprus Conference on New Methods in Drug Research May 21-27, 1989 (p. 22).
Norbeck, Abstract No. 1233 from Abstracts of the Thirty-first Interscience Conference on Antimicrobial Agents and Chemotherapy, Sep. 29-Oct. 2, 1991, Chicago, IL.
Coddington, et al., J. Org. Chem 27 163 (1962).
Saneyoshi, et al., Chem. Pharm. Bull 30 2223 (1982).
Angibeaud, et al., Res. 78 195 (1980).

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