Analogs of oxetanyl purines and pyrimidines

Details Analogs of oxetanyl purines and pyrimidines Analogs of oxetanyl purines and pyrimidines

1993-12-07

1995-05-30

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

549475, 544182, 546268, C07D40504, 549

Patent

active

054202760

ABSTRACT:
A compound of the formula: ##STR1## wherein B is a purin-9-yl group or a heterocyclic isostere of a purin-9-yl group; or a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; A is --CH-- or A--G taken together is --C(.dbd.O)--, --C(.dbd.CH.sub.2)--, --C(OH)(CH.sub.2 OH)-- or ##STR2## and G and D are functional groups; or a pharmaceutically acceptable salt or ester thereof.

REFERENCES:
Jerry March, Advanced Organic Chemistry, 3rd Edition, 1987, p. 975.
Carey et al, Advanced Organic Chemistry, Part B: Reactions and Synthesis, 2nd Edition, 1983 pp. 445-446.
Niitsuma, et al., Tet Lett. 28 4713 (1987).
Shimada, et al., J. of Antibiotics 12 1788 (1987).
Norbeck, et al., J. Am. Chem. Soc. 110 7217 (1988).

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