Analogs of leucascandrolide A

Details Analogs of leucascandrolide A Analogs of leucascandrolide A

2006-02-07

2009-08-04

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S451000, C548S235000, C548S255000, C549S415000

Reexamination Certificate

active

07569594

ABSTRACT:
The present invention describes leucascandrolide analogs of the formula (I), intermediates of the formula (III), pharmaceutical compositions containing the same, methods for preventing cell proliferation, and methods for treating cancers and other proliferative diseases.

REFERENCES:
D'Ambrosio et al. “6.Leucascandrolide A, a New Type of Macrolide: the First Powerfully Bioactive Metabolite of Calcareous Sponges”, Helv. Chim. Acta—vol. 79 (1996), pp. 51-60.
Hornberger et al., “Total Synthesis of Leucascandrolide A”, J. Am. Chem. Soc. 2000, 122, pp. 12894-12895.
Crimmins et al., “Synthesis of the C1-C13 Fragment of Leucasscandrolide A”, Org. Lett., 2000, vol. 2, No. 5, pp. 597-599.
Vakalopoulos et al., “Versatile 8-Oxabicyclo[3.2.1]oct-6-en-3-one: Stereoselective Methodology for Generating C-Glycosides, δ-Valerolactones, and Polyacetate Segments”, Org. Lett., 2001, vol. 3, No. 2, pp. 177-180.
Kozmin et al., “Efficient Stereochemical Relay en Route to Leucascandrolide A”, Org. Lett. 2001, vol. 3, No. 5, pp. 755-758.
Wang et al., “Synthesis of Leucascandrolide A via a Spontaneous Macrolactolization”, J. Am. Chem. Soc. 2002, vol. 124, No. 46, pp. 13670-13671.
Wang et al., “Synthesis of Leucascandrolide A”, Pure Appl. Chem., vol. 77, No. 7, 2005, pp. 1161-1169.
Kozmin et al., PowerPoint presentation entitled “Leucascandrolide A: Using Synthesis to Understand Structure-Activity Profile”, dated Mar. 25, 2003, 21 pages.

Affiliated with

Also associated with

Rating

Analogs of leucascandrolide A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Analogs of leucascandrolide A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Analogs of leucascandrolide A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4062122