Analogs of indole-3-carbinol metabolites as chemotherapeutic...

Details Analogs of indole-3-carbinol metabolites as chemotherapeutic... Analogs of indole-3-carbinol metabolites as chemotherapeutic...

2008-09-05

2010-02-23

Shiao, Rei-tsang (Department: 1628)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S483000, C548S484000

Reexamination Certificate

active

07666897

ABSTRACT:
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of indole-3-carbinol metabolites wherein the structures and substituents of the compounds are selected to enhance the compounds' overall efficacy, particularly with respect to therapeutic activity, oral bioavailability, long-term safety, patient tolerability, and therapeutic window. The compounds are useful not only in treatment of cancer but also in prevention of cancer. One preferred class of the novel compounds has the structure of formula (IV)wherein:R1, R2, R3, R4, R5, R6, R7, R8, R5A, R6A, R7A, R8A, R22and R23are defined herein. Pharmaceutical compositions are provided as well, as are methods of synthesis and use.

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