Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1995-06-19
1998-11-17
Achutamurthy, Ponnathapura
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530811, 530812, 530813, 530816, 514 12, 514 2, C07K 1400
Patent
active
058378081
ABSTRACT:
A tyrosine-substituted hirudin analog has antithrombogenic activity. Further simultaneous reaction at native tyrosine residues is prevented by mutation at those sites to encode nonreactive amino acids. Several novel strategies for coupling the hirudin analog to solid surfaces while simultaneously conserving antithrombogenic activity are disclosed.
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Breillatt, Jr. Julian P.
Johnson Richard
Ku Cecilia S. L.
Achutamurthy Ponnathapura
Baxter International Inc.
Buonauito Mark J.
Fuchs Joseph A.
Wessendorf T. D.
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